Two sample MR report

Telomere_length against aparc-Desikan lh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0020645	0.1181163	0.9862196
Weighted median	23	0.0300917	0.0635126	0.6356487
Inverse variance weighted	23	0.0154145	0.0451237	0.7326474
Simple mode	23	-0.0390796	0.1060885	0.7161195
Weighted mode	23	-0.0111535	0.0977512	0.9101924

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.65064	21	0.0992364
Inverse variance weighted	29.68714	22	0.1262690

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010732	0.0066757	0.8738149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009043	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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