Two sample MR report

Telomere_length against aparc-Desikan lh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0542904	0.1553656	0.7302413
Weighted median	23	0.0173651	0.0645799	0.7880120
Inverse variance weighted	23	0.0318874	0.0593514	0.5910853
Simple mode	23	0.1207481	0.1081103	0.2760884
Weighted mode	23	0.0285571	0.0837481	0.7363475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.29771	21	0.0002401
Inverse variance weighted	51.35765	22	0.0003832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013755	0.0087809	0.8770157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015764	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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