Two sample MR report

Telomere_length against aparc-Desikan lh area parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1609649	0.1137295	0.1716309
Weighted median	23	-0.0821932	0.0626194	0.1893235
Inverse variance weighted	23	-0.0336835	0.0449232	0.4533744
Simple mode	23	0.0747459	0.1312685	0.5748450
Weighted mode	23	-0.1471540	0.0949319	0.1353844

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.48908	21	0.1552450
Inverse variance weighted	29.42413	22	0.1331456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078151	0.0064278	0.237539

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009144	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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