Two sample MR report

Telomere_length against aparc-Desikan lh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0496438	0.1139203	0.6674455
Weighted median	23	0.0621606	0.0541354	0.2508687
Inverse variance weighted	23	0.0098941	0.0436422	0.8206499
Simple mode	23	0.0995856	0.1102232	0.3760525
Weighted mode	23	-0.0284481	0.0751306	0.7085783

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58050	21	0.1524548
Inverse variance weighted	27.76922	22	0.1834562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024406	0.0064385	0.7084441

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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