Two sample MR report

Telomere_length against aparc-Desikan lh area paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0018600	0.1069560	0.9862898
Weighted median	23	-0.0778493	0.0602903	0.1966208
Inverse variance weighted	23	-0.0304654	0.0409168	0.4565319
Simple mode	23	0.0581196	0.1290951	0.6569657
Weighted mode	23	-0.1595780	0.0842908	0.0715618

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.31179	21	0.2781980
Inverse variance weighted	24.40952	22	0.3261349

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017564	0.0060449	0.7742426

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007583	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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