Two sample MR report

Telomere_length against aparc-Desikan lh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0967264	0.0994052	0.3416036
Weighted median	23	-0.0289497	0.0587991	0.6224718
Inverse variance weighted	23	0.0148848	0.0388451	0.7015844
Simple mode	23	-0.0326383	0.1036905	0.7559046
Weighted mode	23	-0.0875974	0.0706133	0.2278495

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.84860	21	0.5308682
Inverse variance weighted	21.33647	22	0.5000355

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006853	0.0056182	0.2360712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000651	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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