Two sample MR report

Telomere_length against aparc-Desikan lh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2443311	0.1302552	0.0746557
Weighted median	23	0.0872231	0.0605396	0.1496523
Inverse variance weighted	23	0.0341129	0.0532457	0.5217377
Simple mode	23	-0.0713607	0.1195981	0.5568179
Weighted mode	23	0.1297236	0.0704255	0.0789968

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.05838	21	0.0215374
Inverse variance weighted	41.33678	22	0.0075126

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0129074	0.0073618	0.0941361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012759	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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