Two sample MR report

Telomere_length against aparc-Desikan lh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0357417	0.1046642	0.7361287
Weighted median	23	0.0539190	0.0645862	0.4038089
Inverse variance weighted	23	0.0032104	0.0400684	0.9361391
Simple mode	23	0.0883359	0.1254570	0.4887494
Weighted mode	23	0.1093964	0.1180840	0.3642757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.28153	21	0.3291536
Inverse variance weighted	23.40793	22	0.3790101

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019975	0.0059155	0.7389675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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