Two sample MR report

Telomere_length against aparc-Desikan lh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0126056	0.1365511	0.9273236
Weighted median	23	0.0092274	0.0649861	0.8870878
Inverse variance weighted	23	-0.0061169	0.0521613	0.9066463
Simple mode	23	-0.0534363	0.1219741	0.6655884
Weighted mode	23	-0.0120853	0.0713473	0.8670401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.62592	21	0.0082551
Inverse variance weighted	39.66779	22	0.0118190

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011496	0.0077176	0.8830113

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012027	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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