Two sample MR report

Telomere_length against aparc-Desikan lh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0566022	0.1369636	0.6836023
Weighted median	23	0.0199431	0.0621468	0.7482838
Inverse variance weighted	23	0.0771316	0.0523242	0.1404521
Simple mode	23	0.0434665	0.1135970	0.7056601
Weighted mode	23	0.0253864	0.0783463	0.7489775

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.86744	21	0.0077177
Inverse variance weighted	39.91778	22	0.0110533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012605	0.0077409	0.8722037

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001329	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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