Two sample MR report

Telomere_length against aparc-Desikan lh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1327738	0.1251803	0.3008914
Weighted median	23	0.0545823	0.0580661	0.3472161
Inverse variance weighted	23	0.0072700	0.0494446	0.8831055
Simple mode	23	0.0606420	0.1233556	0.6278690
Weighted mode	23	0.0328396	0.0675375	0.6316030

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.30087	21	0.0429856
Inverse variance weighted	35.64324	22	0.0331477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085986	0.0070749	0.237711

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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