Two sample MR report

Telomere_length against aparc-Desikan lh area insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1435537	0.1350867	0.2999961
Weighted median	23	-0.0676373	0.0618990	0.2745233
Inverse variance weighted	23	-0.0436935	0.0523604	0.4040128
Simple mode	23	0.1937852	0.1563460	0.2282336
Weighted mode	23	-0.1038580	0.0789996	0.2021632

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.78213	21	0.0104201
Inverse variance weighted	39.97320	22	0.0108899

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061314	0.0076348	0.4309213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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