Two sample MR report

Telomere_length against aparc-Desikan lh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0683554	0.1103231	0.5421904
Weighted median	23	-0.0736951	0.0593714	0.2145109
Inverse variance weighted	23	-0.0488731	0.0421577	0.2463375
Simple mode	23	-0.0873193	0.1176024	0.4656417
Weighted mode	23	-0.0842284	0.0869364	0.3431515

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.86748	21	0.2115473
Inverse variance weighted	25.91281	22	0.2554442

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011962	0.0062353	0.8497041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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