Two sample MR report

Telomere_length against aparc-Desikan lh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1088778	0.1178904	0.3662108
Weighted median	23	0.0367161	0.0579123	0.5260845
Inverse variance weighted	23	0.0534928	0.0473474	0.2585632
Simple mode	23	0.0350319	0.0955282	0.7173329
Weighted mode	23	0.0171799	0.0637273	0.7899919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.53574	21	0.1017218
Inverse variance weighted	32.68458	22	0.0664507

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099695	0.0066629	0.1494612

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010478	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8