Two sample MR report

Telomere_length against aparc-Desikan lh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0716913	0.1021152	0.4903490
Weighted median	23	0.0616740	0.0591208	0.2968614
Inverse variance weighted	23	-0.0240405	0.0399379	0.5472093
Simple mode	23	-0.0034980	0.1106446	0.9750644
Weighted mode	23	0.0480897	0.0726519	0.5148967

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.1604	21	0.3903178
Inverse variance weighted	23.2550	22	0.3874526

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058779	0.0057713	0.3200454

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007163	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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