Two sample MR report

Telomere_length against aparc-Desikan lh area frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0402894	0.1314074	0.7621674
Weighted median	23	-0.0142132	0.0650392	0.8270136
Inverse variance weighted	23	-0.0402180	0.0501699	0.4227633
Simple mode	23	0.0156274	0.1288872	0.9045947
Weighted mode	23	0.0235231	0.0954337	0.8075910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.69716	21	0.0182323
Inverse variance weighted	36.69716	22	0.0255301

Test for directional horizontal pleiotropy

egger_intercept	se	pval
4.4e-06	0.0074268	0.9995342

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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