Two sample MR report

Telomere_length against aparc-Desikan lh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0372739	0.1365292	0.7875118
Weighted median	23	-0.0969792	0.0564234	0.0856552
Inverse variance weighted	23	-0.0951219	0.0523878	0.0694122
Simple mode	23	-0.0269494	0.0906046	0.7689212
Weighted mode	23	-0.0864946	0.0580529	0.1504414

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.61370	21	0.0082832
Inverse variance weighted	40.01338	22	0.0107729

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035518	0.0077163	0.6500282

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013941	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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