Two sample MR report

Telomere_length against aparc-Desikan lh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0041237	0.1326662	0.9754969
Weighted median	23	-0.0751064	0.0611650	0.2194728
Inverse variance weighted	23	0.0034324	0.0506512	0.9459718
Simple mode	23	-0.1532355	0.1123919	0.1865461
Weighted mode	23	0.0141471	0.0780497	0.8578250

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.40540	21	0.0151166
Inverse variance weighted	37.40546	22	0.0213423

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-4.24e-05	0.007498	0.9955372

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011337	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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