Two sample MR report

Telomere_length against aparc-Desikan lh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0726919	0.0994059	0.4726999
Weighted median	23	-0.1100641	0.0559075	0.0489897
Inverse variance weighted	23	-0.1032246	0.0388452	0.0078761
Simple mode	23	-0.1540532	0.0912947	0.1056499
Weighted mode	23	-0.1011490	0.0606891	0.1097545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.84336	21	0.5312013
Inverse variance weighted	19.95471	22	0.5858729

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018747	0.0056182	0.7419266

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008187	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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