Two sample MR report

Telomere_length against aparc-Desikan lh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1553438	0.1009378	0.1387360
Weighted median	23	0.0031134	0.0571430	0.9565487
Inverse variance weighted	23	-0.0128774	0.0414357	0.7559669
Simple mode	23	-0.1391259	0.1032696	0.1916256
Weighted mode	23	0.0201414	0.0636833	0.7547758

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.65167	21	0.4198153
Inverse variance weighted	25.03147	22	0.2955723

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0103287	0.0057048	0.084544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007618	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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