Two sample MR report

Telomere_length against aparc-Desikan lh area bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0691497	0.1108077	0.5393143
Weighted median	23	-0.0658179	0.0594527	0.2682664
Inverse variance weighted	23	-0.0399740	0.0434428	0.3574941
Simple mode	23	-0.0303634	0.1059399	0.7770929
Weighted mode	23	-0.0371910	0.0706244	0.6037386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.09368	21	0.2028994
Inverse variance weighted	27.51595	22	0.1922824

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067001	0.0062626	0.2968206

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008659	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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