Two sample MR report

Telomere_length against aparc-Desikan lh area TotalSurface

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0632576	0.1277149	0.6255291
Weighted median	23	-0.0462627	0.0684996	0.4994400
Inverse variance weighted	23	-0.0447418	0.0487890	0.3591179
Simple mode	23	-0.0890512	0.1344085	0.5145057
Weighted mode	23	-0.0217614	0.1058370	0.8389846

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.66519	21	0.0307171
Inverse variance weighted	34.70614	22	0.0415717

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011369	0.0072182	0.8763542

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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