Two sample MR report

Telomere_length against aparc-DKTatlas rh volume transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1995971	0.0994073	0.0576945
Weighted median	23	-0.0587127	0.0552087	0.2875696
Inverse variance weighted	23	-0.0223094	0.0388460	0.5657633
Simple mode	23	-0.0733926	0.0928269	0.4375947
Weighted mode	23	-0.0899969	0.0581541	0.1359940

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.37173	21	0.8950464
Inverse variance weighted	17.12566	22	0.7563881

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0108854	0.0056183	0.066249

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005289	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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