Two sample MR report

Telomere_length against aparc-DKTatlas rh volume supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0362291	0.1345380	0.7903384
Weighted median	23	-0.0343790	0.0591777	0.5612776
Inverse variance weighted	23	-0.0726288	0.0514709	0.1582253
Simple mode	23	-0.0633707	0.0911772	0.4943138
Weighted mode	23	-0.0471538	0.0745238	0.5334292

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.46783	21	0.0113538
Inverse variance weighted	38.62608	22	0.0155689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022349	0.0076037	0.7717012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012763	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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