Two sample MR report

Telomere_length against aparc-DKTatlas rh volume superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1027499	0.1080635	0.3525074
Weighted median	23	-0.0149676	0.0593004	0.8007293
Inverse variance weighted	23	-0.0464774	0.0415712	0.2635588
Simple mode	23	-0.0286532	0.0993859	0.7758140
Weighted mode	23	-0.0192305	0.0705540	0.7877298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.81806	21	0.2551299
Inverse variance weighted	25.19629	22	0.2877804

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034551	0.0061075	0.5775807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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