Two sample MR report

Telomere_length against aparc-DKTatlas rh volume superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0035118	0.0994068	0.9721524
Weighted median	23	-0.0194657	0.0533840	0.7153832
Inverse variance weighted	23	-0.0191291	0.0388455	0.6224071
Simple mode	23	0.0327382	0.0846938	0.7028045
Weighted mode	23	0.0016679	0.0617618	0.9786991

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.28179	21	0.5670689
Inverse variance weighted	19.31092	22	0.6260585

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009589	0.0056182	0.8661117

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005925	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8