Two sample MR report

Telomere_length against aparc-DKTatlas rh volume superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0891268	0.1318040	0.5062892
Weighted median	23	-0.1430812	0.0556652	0.0101585
Inverse variance weighted	23	-0.0563189	0.0504091	0.2638932
Simple mode	23	-0.1270613	0.1004710	0.2192278
Weighted mode	23	-0.1485158	0.0699054	0.0451034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.92062	21	0.0171907
Inverse variance weighted	37.04918	22	0.0233636

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020144	0.0074494	0.7894798

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011863	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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