Two sample MR report

Telomere_length against aparc-DKTatlas rh volume rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0585781	0.1233738	0.6398285
Weighted median	23	0.0175246	0.0628050	0.7802200
Inverse variance weighted	23	-0.0679093	0.0471111	0.1494517
Simple mode	23	0.0072127	0.1034614	0.9450512
Weighted mode	23	0.0372985	0.0982679	0.7079115

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.34967	21	0.0539444
Inverse variance weighted	32.36007	22	0.0714611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005729	0.0069729	0.9352919

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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