Two sample MR report

Telomere_length against aparc-DKTatlas rh volume rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0151586	0.0994073	0.8802564
Weighted median	23	-0.0801133	0.0546200	0.1424469
Inverse variance weighted	23	-0.0242006	0.0388458	0.5332898
Simple mode	23	-0.0109696	0.0916078	0.9057719
Weighted mode	23	-0.0600455	0.0636534	0.3557627

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.24415	21	0.8105048
Inverse variance weighted	15.25391	22	0.8511128

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005552	0.0056183	0.922221

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000474	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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