Two sample MR report

Telomere_length against aparc-DKTatlas rh volume precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2840378	0.1072135	0.0150011
Weighted median	23	-0.0996516	0.0572092	0.0815295
Inverse variance weighted	23	-0.0233822	0.0472454	0.6206642
Simple mode	23	-0.1182903	0.1008218	0.2532378
Weighted mode	23	-0.1289602	0.0772810	0.1093443

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.42930	21	0.272726
Inverse variance weighted	32.54438	22	0.068577

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0160042	0.0060595	0.0152703

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009971	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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