Two sample MR report

Telomere_length against aparc-DKTatlas rh volume precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1698893	0.1282056	0.1993657
Weighted median	23	-0.0575487	0.0563830	0.3074087
Inverse variance weighted	23	-0.0473012	0.0501894	0.3459603
Simple mode	23	-0.0640086	0.0989938	0.5245848
Weighted mode	23	-0.0767976	0.0677299	0.2690504

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.93144	21	0.0287281
Inverse variance weighted	36.72636	22	0.0253437

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075269	0.0072459	0.31072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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