Two sample MR report

Telomere_length against aparc-DKTatlas rh volume posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1003528	0.1244792	0.4291739
Weighted median	23	-0.0304635	0.0585368	0.6027732
Inverse variance weighted	23	-0.0427114	0.0492569	0.3858797
Simple mode	23	-0.0506836	0.0948407	0.5984191
Weighted mode	23	-0.0191288	0.0590489	0.7490373

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.92944	21	0.0470054
Inverse variance weighted	35.37397	22	0.0353961

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0087841	0.0070352	0.2255601

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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