Two sample MR report

Telomere_length against aparc-DKTatlas rh volume postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2262595	0.1093317	0.0510281
Weighted median	23	-0.1286304	0.0577833	0.0260087
Inverse variance weighted	23	-0.0959924	0.0433750	0.0268920
Simple mode	23	-0.1549122	0.0932483	0.1108418
Weighted mode	23	-0.1438822	0.0598343	0.0250429

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.40379	21	0.2300995
Inverse variance weighted	27.43064	22	0.1953251

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079984	0.0061792	0.209578

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010163	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8