Two sample MR report

Telomere_length against aparc-DKTatlas rh volume pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0617223	0.1097789	0.5799040
Weighted median	23	0.0500784	0.0645021	0.4375219
Inverse variance weighted	23	0.0188814	0.0425434	0.6571754
Simple mode	23	0.0119385	0.1199190	0.9215996
Weighted mode	23	0.0384072	0.0999820	0.7045616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.61289	21	0.2215956
Inverse variance weighted	26.38892	22	0.2353588

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049491	0.0062045	0.4339929

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008068	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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