Two sample MR report

Telomere_length against aparc-DKTatlas rh volume parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0502524	0.1372703	0.7179650
Weighted median	23	-0.0021861	0.0582112	0.9700427
Inverse variance weighted	23	-0.0022391	0.0526237	0.9660609
Simple mode	23	0.0594092	0.1241887	0.6371004
Weighted mode	23	-0.0376231	0.0694404	0.5933995

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.04488	21	0.0073439
Inverse variance weighted	40.37398	22	0.0097736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003223	0.0077582	0.6820431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012234	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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