Two sample MR report

Telomere_length against aparc-DKTatlas rh volume parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0036974	0.1025478	0.9715789
Weighted median	23	0.0099429	0.0592627	0.8667589
Inverse variance weighted	23	-0.0034594	0.0391517	0.9295908
Simple mode	23	0.0839904	0.1015268	0.4169657
Weighted mode	23	0.0293415	0.0742154	0.6963877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.34710	21	0.3797499
Inverse variance weighted	22.34711	22	0.4393411

Test for directional horizontal pleiotropy

egger_intercept	se	pval
1.46e-05	0.0057958	0.9980125

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006774	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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