Two sample MR report

Telomere_length against aparc-DKTatlas rh volume parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2311835	0.1132143	0.0539113
Weighted median	23	-0.1080080	0.0583907	0.0643499
Inverse variance weighted	23	-0.0668710	0.0457114	0.1434959
Simple mode	23	-0.0915317	0.1100659	0.4145657
Weighted mode	23	-0.1405717	0.0620425	0.0336539

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.24066	21	0.1630287
Inverse variance weighted	30.46546	22	0.1075832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100888	0.0063986	0.1298077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001013	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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