Two sample MR report

Telomere_length against aparc-DKTatlas rh volume parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0156438	0.1121676	0.8904092
Weighted median	23	0.0193925	0.0551637	0.7251791
Inverse variance weighted	23	0.0422377	0.0431437	0.3275791
Simple mode	23	0.0142393	0.0799815	0.8603265
Weighted mode	23	0.0038062	0.0555019	0.9459456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.73771	21	0.1797044
Inverse variance weighted	27.13786	22	0.2060372

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035539	0.0063394	0.5810012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008581	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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