Two sample MR report

Telomere_length against aparc-DKTatlas rh volume paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1490213	0.1251874	0.2471781
Weighted median	23	-0.0709467	0.0573970	0.2164323
Inverse variance weighted	23	-0.0126771	0.0493631	0.7973230
Simple mode	23	0.0310004	0.1187387	0.7964585
Weighted mode	23	-0.0816201	0.0719332	0.2687275

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.30656	21	0.0429264
Inverse variance weighted	35.52695	22	0.0341025

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083715	0.0070753	0.2499511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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