Two sample MR report

Telomere_length against aparc-DKTatlas rh volume middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1307798	0.0994032	0.2024751
Weighted median	23	0.0830562	0.0590520	0.1595781
Inverse variance weighted	23	0.0259554	0.0388447	0.5040169
Simple mode	23	0.1069952	0.1037223	0.3134885
Weighted mode	23	0.1069952	0.0969211	0.2815474

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.73397	21	0.6657716
Inverse variance weighted	20.66823	22	0.5413149

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096237	0.0056181	0.1014453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006398	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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