Two sample MR report

Telomere_length against aparc-DKTatlas rh volume medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0401192	0.1520343	0.7944425
Weighted median	23	0.0623446	0.0698509	0.3721045
Inverse variance weighted	23	-0.0117524	0.0582355	0.8400662
Simple mode	23	0.1301971	0.1650391	0.4385978
Weighted mode	23	0.1443520	0.1570483	0.3679821

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.12708	21	0.0004819
Inverse variance weighted	49.44848	22	0.0006959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003185	0.0085928	0.7146055

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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