Two sample MR report

Telomere_length against aparc-DKTatlas rh volume lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1775231	0.1111261	0.1250951
Weighted median	23	0.0471282	0.0630307	0.4546396
Inverse variance weighted	23	0.0136776	0.0458209	0.7653206
Simple mode	23	0.1467680	0.1116390	0.2021629
Weighted mode	23	0.0826751	0.0778953	0.3000388

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.24457	21	0.1972767
Inverse variance weighted	30.61107	22	0.1043529

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117397	0.0062806	0.0756055

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009314	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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