Two sample MR report

Telomere_length against aparc-DKTatlas rh volume lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0692875	0.1289723	0.5967574
Weighted median	23	0.0027869	0.0645634	0.9655703
Inverse variance weighted	23	-0.0052219	0.0497000	0.9163220
Simple mode	23	0.0151880	0.1107810	0.8921996
Weighted mode	23	0.0067677	0.0951773	0.9439556

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.35079	21	0.0258306
Inverse variance weighted	36.01388	22	0.0302624

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045749	0.0072893	0.5370183

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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