Two sample MR report

Telomere_length against aparc-DKTatlas rh volume lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1026971	0.1193247	0.3991494
Weighted median	23	-0.0391573	0.0579798	0.4994465
Inverse variance weighted	23	-0.0182722	0.0461930	0.6924281
Simple mode	23	-0.0503399	0.0978246	0.6119685
Weighted mode	23	-0.0464192	0.0700802	0.5146117

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.25895	21	0.0869067
Inverse variance weighted	31.11024	22	0.0938817

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051837	0.0067439	0.4506662

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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