Two sample MR report

Telomere_length against aparc-DKTatlas rh volume isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0530962	0.1309409	0.6892133
Weighted median	23	0.0796772	0.0556193	0.1519878
Inverse variance weighted	23	0.0047264	0.0502649	0.9250853
Simple mode	23	0.0898594	0.0957252	0.3580656
Weighted mode	23	0.0827911	0.0596272	0.1788903

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.43724	21	0.0195166
Inverse variance weighted	36.83657	22	0.0246512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035503	0.0074005	0.6363719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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