Two sample MR report

Telomere_length against aparc-DKTatlas rh volume insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1213446	0.1215314	0.3294215
Weighted median	23	0.0055752	0.0570439	0.9221432
Inverse variance weighted	23	0.0253430	0.0482615	0.5995008
Simple mode	23	0.1933622	0.1122914	0.0991076
Weighted mode	23	0.0020553	0.0637768	0.9745815

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.38861	21	0.0674292
Inverse variance weighted	33.95858	22	0.0496026

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090065	0.0068686	0.2039285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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