Two sample MR report

Telomere_length against aparc-DKTatlas rh volume inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0350796	0.1269528	0.7850036
Weighted median	23	0.0442604	0.0622393	0.4770016
Inverse variance weighted	23	-0.0388826	0.0484716	0.4224528
Simple mode	23	0.0347131	0.1207686	0.7764691
Weighted mode	23	0.0458112	0.0945088	0.6326595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.25451	21	0.0340292
Inverse variance weighted	34.25623	22	0.0462543

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002335	0.0071752	0.9743457

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010683	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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