Two sample MR report

Telomere_length against aparc-DKTatlas rh volume inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0155187	0.1212019	0.8993353
Weighted median	23	-0.0883820	0.0570516	0.1213439
Inverse variance weighted	23	-0.0459511	0.0463555	0.3215514
Simple mode	23	-0.0654183	0.1050633	0.5399119
Weighted mode	23	-0.0618400	0.0631929	0.3384214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.21868	21	0.0700948
Inverse variance weighted	31.32929	22	0.0895717

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018685	0.00685	0.7876885

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009917	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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