Two sample MR report

Telomere_length against aparc-DKTatlas rh volume fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0037984	0.1020536	0.9706616
Weighted median	23	-0.0369541	0.0555571	0.5059514
Inverse variance weighted	23	-0.0355374	0.0391253	0.3637207
Simple mode	23	-0.0963580	0.0807932	0.2457115
Weighted mode	23	-0.0457044	0.0615082	0.4653063

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.13316	21	0.3918713
Inverse variance weighted	22.31797	22	0.4410527

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024152	0.0057678	0.6796595

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007016	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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