Two sample MR report

Telomere_length against aparc-DKTatlas rh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0149678	0.0994061	0.8817505
Weighted median	23	0.0320653	0.0564745	0.5701821
Inverse variance weighted	23	0.0048146	0.0388456	0.9013617
Simple mode	23	0.0404306	0.0858069	0.6421502
Weighted mode	23	0.0343733	0.0610007	0.5787998

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.99887	21	0.7697145
Inverse variance weighted	16.01118	22	0.8153303

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006234	0.0056182	0.9127006

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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